Abstract With the introduction of novel therapeutic agents, survival in Multiple Myeloma (MM) has increased in recent years.However, drug-resistant clones inevitably arise and lead to disease progression and death.The current International Myeloma Working Group response criteria are broad and make it difficult to clearly designate resistant and mot
Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes
Tissue-resident intestinal intraepithelial T lymphocytes (T-IEL) patrol the gut and have important roles in regulating intestinal homeostasis.T-IEL include both induced T-IEL, derived from systemic antigen-experienced lymphocytes, and natural T-IEL, which are developmentally targeted to the intestine.While the processes driving satisfyer pro pengui
Occurrence of pathogenic and faecal Escherichia coli in layer hens
A total of 117 Escherichia coli from colibacillosis affected (APEC) and clinically healthy birds (AFEC) were chocolate chip cookie purse serotyped and tested for the presence of virulence genes: iss, tsh, cva.A total of 54.5% E.Coli were typeable and 15 different serogroups were identified.The most common serogroups among APEC strains were O78, O2
An SDNFV-Based DDoS Defense Technology for Smart Cities
A software defined networking (SDN)-enabled smart city is a new paradigm that can effectively improve the cost efficiency and flexibility of data management through data-control separation.However, it faces significant security threats such as distributed denial of service (DDoS) attacks which jeopardize the security and availability of data and se
Implementation with ex post hidden actions
In this paper, we study implementation in settings where agents take strategic actions that influence preferences over mechanism outcomes and yet are hidden from the mechanism designer.We show that such settings can arise in entry auctions for markets, and that the Vickery-Clarke-Groves Mechanism is not guaranteed to be truthful because of strategi